Facilitatory and inhibitory transmitters modulate spontaneous transmitter release at cultured Aplysia sensorimotor synapses.
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چکیده
منابع مشابه
Facilitation of transmitter release at squid synapses
Facilitation is shown to decay as a compound exponential with two time constants (T1, T2) at both giant and non-giant synapses in squid stellate ganglia bathed in solutions having low extracellular calcium concentrations ([Ca++]o). Maximum values of facilitation (F1) were significantly larger, and T1 was significantly smaller in giant than non-giant synapses. Decreases in [Ca++]o or increases ...
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19 Aplysia sensorimotor synapses provide a useful model system for analyzing molecular 20 processes that contribute to heterosynaptic plasticity. For example, previous studies 21 demonstrated that multiple kinase cascades contribute to serotonin (5-HT)-induced 22 short-term synaptic facilitation (STF), including protein kinase A (PKA) and protein 23 kinase C (PKC). Moreover, the contribution of...
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An Aplysia motor neuron cocultured with a single presynaptic sensory neuron exhibits spontaneous miniature EPSPs or EPSCs ("minis") that can be used to assay the release process directly, independent of the presynaptic action potential. Sensory-motor synapses in culture undergo homosynaptic depression with low frequency stimulation (< 1 Hz) and posttetanic potentiation (PTP) with high-frequency...
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A subcellular fraction (P3) from Aplysia is enriched in synaptosomes (Chin et al., 1988) and is capable of accumulating 5-HT and choline. At an external 3H-5-HT concentration of 1.8 microM, the P3 fraction took up 0.12 nmol/mg protein in 30 min. Uptake was dependent on external Na+. Electron microscopic autoradiography showed that much of the accumulated 3H-5-HT is localized to synaptosomes. At...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1990
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1990.sp017941